Complement Assays

The increased awareness and interest in the complement system has augmented the need for a simple and objective method to assess the function of complement activity.

With the Euro Diagnostica complement assay solution a complete picture of the complement function is provided.

Reasons to analyze complement

Complement is an essential part of the innate immunity and therefore disturbances of the complement system leads to infections, amplify diseases etc. The complement function testing also verifies the effect of certain treatments. Therefore it is important to analyze the functional activity of the system. 

Three major reasons to study complement function:

1. Complement deficiencies are associated with infections and autoimmune diseases. Deficiencies of the classical pathway are often associated with SLE, glomerulonephritis and susceptibility to infections. Deficiencies of the alternative pathway often leads to Neisserial infections etc. An excellent way to screen for deficiencies is to study the function of the three pathways of the system. 

2. Activation of the complement system is part of active autoimmune diseases and therefore reflects ongoing disease processes.For example in SLE it is important to follow activity of disease since complement activation follows disease activity and can detect flares. 

3. New therapies are aiming at stopping or increasing complement activityand therefore complement function is important to assess. An example is the anti-C5 monoclonal antibody therapy, where complement function testing verifies effect of the treatment. 

Complement product portfolio

Product Name                                                          Description 

Complement system screen                                ELISA kit for total functional assessment of the CP, AP, LP     

Complement system classical pathway           ELISA kit for total functional assessment of the Classical pathway

Complement system MBL pathway                   ELISA kit for total functional assessment of the Lectin pathway (MBL)

Complement system alternative pathway       ELISA kit for total functional assessment of the Alternative pathway